Cisplatin magnesium wasting

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August undefined, 2024

WebCisplatin is a coordinate metal complex with significant antineoplastic activity and various effects, including acute anc chronic renal insufficiency and renal magnesium wasting. Nephrotoxicity may occur in as many as 50% to 75% of patients receiving the drug, and is apparently due to renal tubular injury. WebFeb 1, 1999 · Since the magnesium reabsorption process still remains to be fully characterized, the effect by cisplatin on this process remains uncertain. …

Chapter 11. Chemotherapy and Kidney Injury - American …

WebMagnesium plays an important role in the maintenance of intracellular K. An unrecognized and untreated Mg depletion can lead to a refractory K repletion. We describe two … WebJan 12, 2024 · Hypomagnesemia is often associated with hypokalemia (due to urinary potassium wasting) and hypocalcemia (due both to lower parathyroid hormone secretion … describe hatch and slack pathway

Chapter 5: Electrolyte and Acid Base Disorders in Malignancy

WebApr 5, 2024 · Magnesium is another supplement that has been shown to be helpful in reducing cisplatin related toxicity. Solanki et al. have noted in their mice studies that a deficiency of magnesium amplifies markers of renal damage which is promptly reversed by supplementation with magnesium. WebAfter filtration, approximately 10% to 20% of reabsorption occurs in the proximal tubule through paracellular pathways and driven by electrochemical gradients favoring magnesium movement out of the latter parts of the proximal tubule., Next, 50% to 70% of magnesium is reabsorbed in the thick ascending limb of the loop of Henle (TAL; Figure 2 ), … WebOct 1, 2024 · Cisplatin injury to renal tubules often impacts magnesium reabsorption, resulting in renal magnesium wasting and hypomagnesemia . Earlier studies suggest that cisplatin induces hypomagnesemia in 40–90% of patients receiving the treatment, and magnesium loss in turn aggravates cisplatin nephrotoxicity ( 3 , 5 ). describe healing in terms of reeda

Identifying cisplatin-induced kidney damage in paediatric …

WebMay 24, 2006 · Magnesium wasting in the proximal tubule and thick ascending limb should result in a fractional excretion greater than 10%. Metabolic alkalosis and hypokalemia may also have a role in magnesium excretion. Treatment of GS requires correction of the serum electrolyte abnormalities [ 2 ]. WebOct 1, 2024 · Some authors point to the beneficial effect of magnesium supplementation in fluid therapy employed before and after the administration of cisplatin/carboplatin (magnesium supplementation... chrysler pt cruiser radioWebwasting due to cisplatin therapy. Although patients with cancer have hyponatremia due to many etiologies (Table 1), SIADH is the most common etiol- ... drugs, where renal magnesium wasting can be permanent. Hypercalcemia Twenty percent to 30% of cancer patients experience hypercal-cemia during the course of their malignancy (19), and this is describe healthy mental functioning

"WebRenal magnesium wasting may be part of a primary inherited disorder (Gitelman's syndrome),12, 13a single defect in magnesium reabsorption,14or associated with several other clinical disorders.2, 4Excessive urinary losses of magnesium can also be associated with diabetic ketoacidosis, hyperaldosteronism, hypercalciuria (with concomitant use of … " - Cisplatin magnesium wasting

Cisplatin magnesium wasting

Hypomagnesemia and renal magnesium wasting in …

WebWe documented inappropriate renal magnesium wasting in four patients. Two patients required hospitalization for symptomatic hypomagnesemia. We conclude that cisplatin …

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WebNational Center for Biotechnology Information WebJul 11, 2003 · Cisplatin is not directly toxic to bone, but cisplatin nephrotoxicity leading to magnesium wasting may affect magnesium and calcium metabolism, both of which contribute to bone integrity. The specificity of the magnesium lesion suggests that cisplatin may have an affinity for proteins that regulate magnesium absorption.

WebSep 9, 2024 · 17q12 deletion syndrome encompasses a broad constellation of clinical phenotypes, including renal magnesium wasting, maturity-onset diabetes of the young (MODY), renal cysts, genitourinary malformations, and neuropsychiatric illness. Manifestations outside of the renal, endocrine, and nervous systems have not been well … WebMagnesium plays an important role in the maintenance of intracellular K. An unrecognized and untreated Mg depletion can lead to a refractory K repletion. We describe two patients with hypomagnesemia-associated refractory hypokalemia following cisplatin therapy. Potassium supplementation failed to replace the K deficit.

WebSodium and potassium disorders are pervasive in patients with cancer. these abnormalities are wide-ranging, are often primary or second-order consequences of the underlying cancer, and have prognostic implications. The approach to hyponatremia should focus on cancer-related etiologies, such as syndrome of inappropriate antidiuretic WebCisplatin (cis-diamminedichloroplatinum II), a chemotherapeutic agent used against epithelial neoplasms, is known to cause hypomagnesemia and renal magnesium …

Web• Cisplatin (cis-diamminedichloroplatinum II), a chemotherapeutic agent used against epithelial neoplasms, is known to cause hypomagnesemia and renal magnesium …

WebAug 16, 2024 · A single-region retrospective study from central Texas at Baylor Scott & White Cancer Clinics who were treated with two or more cycles of cisplatin were included. Standard hydration for this study was defined as normal saline before and after cisplatin along with potassium chloride 10 mEq and magnesium sulfate 1 g added to the … describe head and neck anatomy skullWebNational Center for Biotechnology Information describe health belief modelWebCisplatin is a chemotherapy drug used to treat some forms of cancer. Note: ... Severe magnesium deficiency caused by cisplatin therapy has been reported to result in … chrysler pt cruiser radiator replacement costWebJan 11, 2024 · Cisplatin commonly causes magnesium and potassium wasting, and electrolytes should be replaced as appropriate. The administration of 1 g magnesium intravenously with cisplatin might help to reduce ... chrysler pt cruiser road ripperWeb• Cisplatin (cis-diamminedichloroplatinum II), a chemotherapeutic agent used against epithelial neoplasms, is known to cause hypomagnesemia and renal magnesium wasting. In order to further characterize the effect of multiple doses of this drug upon serum magnesium levels and renal magnesium handling, we prospectively stud ied 28 … chrysler pt cruiser repair manual freeWeb42%–100% of patients depending on total cisplatin dose and length of exposure. Hypomagnesemia and renal magnesium wasting may persist for up to 6 years after initial dose (5). Renal salt wasting syndrome has been reported in up to 10% of patients, manifesting as hyponatremia and severe ortho-static hypotension in the setting of high … chrysler pt cruiser sbazarWebAbstract. Purpose: Administration of cisplatin causes changes in magnesium and potassium metabolism. The purpose of this study was to investigate day-to-day changes in renal and intestinal homeostasis of magnesium (Mg) and potassium (K) during repeated cisplatin treatments in rats to provide guidelines for human supplementation studies. chrysler pt cruiser reviews 2005