WebThe concentrations of HSA used were 4% to 2% or 0.6 to 0.3 m M, while different ligand concentrations were 1μ M to 1 m M. Structural data showed drugs are mostly located … WebA total of five specific binding sites were identified for HSA, including the cysteine residue C34, two methionine sites (M329, M548) and the tyrosine and aspartate O-donor sites Y150 (or Y148) and D375 (or E376). Methionine-256 was established as a cisplatin coordination site for Trfe in addition to the O-donor sites E265, Y314, E385 and T457.
RCSB PDB - 4S1Y: X-ray structure of human serum albumin …
WebThe major cisplatin binding site appears to be an S,N-macrochelate involving Met298 as a ligand. Apart from Met298, Met87 and Met446 were also proposed to be . involved in the formation of monofunctional adducts with cisplatin since these residues appear to be ... Crystal structure of Human Serum Albumin (from ref. 14). WebThe reaction between cisplatin and human serum albumin (HSA) was investigated by X-ray crystallography and crystal structures of the … iphone has water damage
Cisplatin binding to human serum albumin: a structural study
WebDec 1, 2013 · Human serum albumin (HSA) is a major protein component of blood plasma and plays an important role in the regulation of colloidal osmotic pressure and the transport of numerous endogenous compounds such as fatty acids, hormones, toxic metabolites (e.g. bilirubin), bile acids, amino acids, and metals [1], [2], [3], [4]. Web: Migration and invasion enhancer 1 (MIEN1) is a membrane-anchored protein and exists in various cancerous tissues. However, the roles of MIEN1 in prostate cancer have not yet been clearly addressed. We determined the expression, biological functions, and regulatory mechanisms of MIEN1 in the prostate. The results of immunohistochemical analysis … WebCisplatin, cis - [Pt (Cl 2 (NH 3) 2 ], can crosslink residues His67 of domain I and His247 of domain II in human albumin, occupying the major binding site for the essential metal … orange cardinal bird